Fast excitatory transmission at synapses of the central nervous system is mainly mediated by AMPA receptors (AMPARs). Synaptic AMPAR number and function correlates with synaptic strength. AMPARs are thus key proteins of activity-dependent plasticity in neuronal communication. Up- or down-regulation of synaptic AMPAR number is a tightly controlled dynamic process that involves export of receptors from the endoplasmic reticulum (ER) and Golgi apparatus, exocytosis and endocytosis as well as lateral diffusion of the receptors in the cell membrane. The four AMPAR subunits are embedded into a dynamic network of more than 30 interacting proteins. Many of these proteins are known to modulate receptor gating, trafficking and subcellular localization. Here, we will review the influence that AMPAR interacting proteins exert on trafficking and subcellular localization of the receptors by controlling their assembly, ER/Golgi apparatus export, and synaptic anchoring.

中枢神经系统突触的快速兴奋性传递主要由AMPA受体（AMPAR）介导。突触的AMPAR数量和功能与突触强度相关。因此，AMPAR是神经元沟通中活动依赖性可塑性的关键蛋白。突触AMPAR数的上调或下调是一个严格控制的动态过程，涉及从内质网（ER）和高尔基体中输出受体，胞吐作用和内吞作用以及受体在细胞膜中的横向扩散。四个AMPAR亚基被嵌入到由30多种相互作用的蛋白质组成的动态网络中。已知许多这些蛋白可调节受体门控，转运和亚细胞定位。这里，