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Mussel-Inspired Peptide Coatings on Titanium Implant to Improve Osseointegration in Osteoporotic Condition
ACS Biomaterials Science & Engineering ( IF 5.4 ) Pub Date : 2018-05-26 00:00:00 , DOI: 10.1021/acsbiomaterials.8b00261 Huan Zhao 1, 2 , Yingkang Huang 1, 2 , Wen Zhang 1, 2 , Qianping Guo 2 , Wenguo Cui 2 , Zhiyong Sun 1 , David Eglin 3 , Lei Liu 4 , Guoqing Pan 4 , Qin Shi 1, 2, 5
ACS Biomaterials Science & Engineering ( IF 5.4 ) Pub Date : 2018-05-26 00:00:00 , DOI: 10.1021/acsbiomaterials.8b00261 Huan Zhao 1, 2 , Yingkang Huang 1, 2 , Wen Zhang 1, 2 , Qianping Guo 2 , Wenguo Cui 2 , Zhiyong Sun 1 , David Eglin 3 , Lei Liu 4 , Guoqing Pan 4 , Qin Shi 1, 2, 5
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Osteoporosis greatly impairs in vivo implant osseointegration because of poor osteogenesis in osteoporotic conditions and the low bioactivity of implants, such as titanium-based biomaterials. Various surface engineering strategies, including unstable physical absorption or complex chemical conjugations, have been developed to biofunctionalize titanium implants and improve interfacial osseointegration. However, very few of them took into consideration the clinically challenging osteoporotic condition, as well as dual-functionalization of the implants for improvement of both osteoblast adhesion and osteogenesis. In this work, we combined two mussel-inspired bioactive peptides (i.e., with cell adhesive or osteogenic sequences) for one-step dual-functionalization of Ti screws via a facile self-organized multivalent coordinative interaction. In vitro study indicated that the biomimetic dual-functional coating could efficiently improve the osteogenesis of osteoporosis-derived mesenchymal stem cells despite of their impaired bone metabolism. Moreover, under osteoporotic in vivo condition, the dual-functional peptide coating on Ti screws could also give rise to significant enhancement of interfacial osteogenesis, newly formed bone condition, osseointegration, as well as implant mechanical stability. This is probably due to the integrin-targeted cell adhesive and osteogenic motifs on the modified Ti screws, which recovered the regular bone metabolism equilibrium between osteogenesis and osteoclastogenesis in an osteoporotic condition. We anticipate that the highly biomimetic peptides and one-step dual-functionalized strategy would provide a facile and effective means for improving the clinical outcome of Ti-based implants in patients with a disturbed bone metabolism.
中文翻译：
钛植入物上的贻贝启发肽涂层，可改善骨质疏松情况下的骨整合。
由于骨质疏松条件下的成骨性较差以及植入物（如钛基生物材料）的生物活性低，骨质疏松症严重损害了体内植入物的骨整合。已经开发了各种表面工程策略，包括不稳定的物理吸收或复杂的化学共轭，以生物功能化钛植入物并改善界面骨整合。但是，他们中很少有人考虑到临床上具有挑战性的骨质疏松症，以及植入物的双重功能化，以改善成骨细胞的粘附性和成骨性。在这项工作中，我们通过方便的自组织多价配位相互作用将两种贻贝启发的生物活性肽（即具有细胞黏附或成骨序列）结合在一起，用于Ti螺钉的一步双功能化。体外研究表明，仿生双功能涂层可以有效改善骨质疏松来源的间充质干细胞的成骨性，尽管它们的骨代谢受损。此外，在体内骨质疏松的情况下，钛螺钉上的双功能肽涂层还可显着增强界面成骨作用，新形成的骨状况，骨整合以及植入物的机械稳定性。这可能是由于以整联蛋白为靶标的细胞粘附剂和修饰的Ti螺钉上的成骨基序，它们在骨质疏松症条件下恢复了成骨和破骨细胞生成之间的常规骨代谢平衡。
更新日期：2018-05-26
中文翻译：
钛植入物上的贻贝启发肽涂层，可改善骨质疏松情况下的骨整合。
由于骨质疏松条件下的成骨性较差以及植入物（如钛基生物材料）的生物活性低，骨质疏松症严重损害了体内植入物的骨整合。已经开发了各种表面工程策略，包括不稳定的物理吸收或复杂的化学共轭，以生物功能化钛植入物并改善界面骨整合。但是，他们中很少有人考虑到临床上具有挑战性的骨质疏松症，以及植入物的双重功能化，以改善成骨细胞的粘附性和成骨性。在这项工作中，我们通过方便的自组织多价配位相互作用将两种贻贝启发的生物活性肽（即具有细胞黏附或成骨序列）结合在一起，用于Ti螺钉的一步双功能化。体外研究表明，仿生双功能涂层可以有效改善骨质疏松来源的间充质干细胞的成骨性，尽管它们的骨代谢受损。此外，在体内骨质疏松的情况下，钛螺钉上的双功能肽涂层还可显着增强界面成骨作用，新形成的骨状况，骨整合以及植入物的机械稳定性。这可能是由于以整联蛋白为靶标的细胞粘附剂和修饰的Ti螺钉上的成骨基序，它们在骨质疏松症条件下恢复了成骨和破骨细胞生成之间的常规骨代谢平衡。
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