This study aimed at identifying seaweed species with optimal characteristics to develop multifunctional foods for metabolic syndrome (MetS) management. Mass spectrometry chemical characterization and bioactive profile evaluation of methanolic extracts from seven commonly consumed seaweeds were compared. Monomeric sugars namely mannitol, fucitol, xylitol and their sulphated analogs as well as lipids (phosphatidic acid, octadecenoic acid, and prostaglandin 2α) were detected in seaweeds. Himanthalia elongata showed the highest phenolic content (24.04 µmol GAE/g), and antioxidant activity. This species was the only one showing angiotensin converting enzyme-I inhibitory activity (IC₅₀ = 65 µg/mL). U. pinnatifida and H. elongata extracts were notably more effective reducing pro-inflammatory molecules in lipopolysaccharide-induced RAW 264.7 macrophages. Finally, Ulva spp., Palmaria palmata, U. pinnatifida and H. elongata significantly inhibited triglyceride accumulation in mature 3T3-L1 adipocytes (43–52% inhibition). Among seaweeds, H. elongata showed the highest potential to be used as ingredient in the development of new functional foods for MetS management.

这项研究旨在鉴定具有最佳特征的海藻物种，以开发用于代谢综合症（MetS）管理的多功能食品。比较了七种常用海藻中甲醇提取物的质谱化学表征和生物活性特征评估。在海藻中检出了单体糖，即甘露醇，果糖醇，木糖醇及其硫酸化类似物以及脂质（磷脂酸，十八烯酸和前列腺素2α）。Himanthalia elongata表现出最高的酚含量（24.04 µmol GAE / g）和抗氧化活性。该物种是唯一显示出血管紧张素转化酶-I抑制活性的物种（IC ₅₀  = 65 µg / mL）。pinnatifida和H.elongata提取物在减少脂多糖诱导的RAW 264.7巨噬细胞中的促炎分子方面尤其有效。最后，Ulva spp。，Palaria palmata，U。pinnatifida和H. elongata显着抑制了成熟3T3-L1脂肪细胞中甘油三酸酯的积累（抑制43-52％）。在海藻中，伸长的H. elongata展示出在开发用于MetS管理的新功能食品中用作成分的最大潜力。