This study was aimed at investigating the immunomodulating activities of molokhia leaf extract. To examine the immunomodulatory activities of a water-soluble molokhia (Corchorus olitorius) leaf extract (WME), nitric oxide (NO) and cytokine levels in relation to macrophage activation were estimated in a cyclophosphamide-induced murine model of immunosuppression, and a natural killer (NK) cell cytotoxicity assay was conducted. Administration of WME significantly augmented NK cell cytotoxicity against YAC-1 cells by inducing the release of granzyme B. In addition, murine peritoneal macrophages stimulated by WME produced various cytokines, including tumor necrosis factor (TNF)-α and interleukin (IL)-6. The results of this study showed that WME administration (50 and 100 mg/kg) increased thymus and spleen indices, and the leukocyte count in the blood of immunosuppressed mice. These results demonstrated that WME possesses immunomodulatory activity and may represent a potential immunostimulant for enhancing human immunity.

这项研究旨在调查莫洛希亚叶提取物的免疫调节活性。为了检查水溶性莫洛希亚（Corchorus olitorius）的免疫调节活性）在环磷酰胺诱导的鼠免疫抑制模型中估算了叶提取物（WME），一氧化氮（NO）和细胞因子与巨噬细胞活化相关的水平，并进行了自然杀伤（NK）细胞毒性试验。通过诱导颗粒酶B的释放，WME的给药显着增强了NK细胞对YAC-1细胞的细胞毒性。此外，WME刺激的鼠腹膜巨噬细胞产生了多种细胞因子，包括肿瘤坏死因子（TNF）-α和白介素（IL）-6 。这项研究的结果表明，以WME给药（50和100 mg / kg）可增加免疫抑制小鼠血液中的胸腺和脾脏指数，并增加白细胞计数。这些结果表明，WME具有免疫调节活性，可能代表增强人类免疫力的潜在免疫刺激剂。