Abstract In this work novel hybrid materials for drug delivery purposes are obtained by combining keratin with hydrotalcite nanoparticles containing diclofenac. The hybrid films showed a less pronounced swelling, porosity and degradation and a greater thermal stability compared to pure keratin films containing free diclofenac. These results, together with the slight shift towards smaller wavelength numbers of amide I band led to the hypothesis of a probable cross-linking between hydrotalcites and the protein mediated by glutaraldehyde, which results in a total reinforcing action on the hybrid material. In addition, diclofenac release profiles of the hybrid film in physiological conditions were higher than those of the non-hybrid compound. Furthermore, keratin/hydrotalcite were able to support fibroblast cells adhesion and growth suggesting their potential use as drug delivery systems for wound healing and tissue engineering applications.

中文翻译：

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用于药物递送应用的角蛋白-水滑石混合膜

摘要 在这项工作中，通过将角蛋白与含有双氯芬酸的水滑石纳米颗粒相结合，获得了用于药物递送的新型混合材料。与含有游离双氯芬酸的纯角蛋白膜相比，混合膜显示出不太明显的溶胀、孔隙率和降解以及更高的热稳定性。这些结果，连同酰胺 I 波段向较小波长数的轻微偏移，导致了水滑石和由戊二醛介导的蛋白质之间可能发生交联的假设，这导致对杂化材料的全面增强作用。此外，混合膜在生理条件下的双氯芬酸释放曲线高于非混合化合物的释放曲线。此外，