Resveratrol (Res), a natural polyphenol present in different plants and vegetables, exhibits potential therapeutic activity with cardioprotective, antineurodegenerative, antioxidant, and antitumor action. In this study, the effect of Res on the mutual interactions between positively charged poly-l-lysine (PLL) and negatively charged dipalmitoylphosphatidylcholine/dipalmitoylphosphatidylglycerol (DPPC/DPPG) membranes was studied using Fourier-transform infrared (FTIR) spectroscopy supported by principal component analysis (PCA). The interactions between PLL and DPPC/DPPG membranes were strongly affected by the presence of Res molecules. Depending on the Res concentration and method of its supply (through the water or lipid phase) to the studied peptide–membrane systems, the membrane-induced transition of PLL from an α-helix to an extended left-handed polyproline II helix (PPII) occurred at different temperatures, with different cooperativity, or was even completely suppressed. The influence of PLL on the conformational (trans/gauche) state of the hydrocarbon chain region of the lipid membranes and the hydration state of the polar/apolar membrane interface was also modulated by Res, depending on the membrane phase state.

白藜芦醇（Res）是存在于不同植物和蔬菜中的天然多酚，具有潜在的治疗活性，具有心脏保护作用，抗神经变性，抗氧化剂和抗肿瘤作用。在这项研究中，RES对积极的相互交互的效果带电聚升使用主要成分分析（PCA）支持的傅立叶变换红外（FTIR）光谱研究了赖氨酸（PLL）和带负电荷的二棕榈酰磷脂酰胆碱/二棕榈酰磷脂酰甘油（DPPC / DPPG）膜。Res分子的存在强烈影响PLL与DPPC / DPPG膜之间的相互作用。取决于Res浓度及其（通过水或脂质相）供应给所研究的肽-膜系统的方法，膜诱导的PLL从α螺旋过渡到延伸的左手多脯氨酸II螺旋（PPII）的转变发生在不同的温度下，具有不同的合作性，甚至被完全抑制。PLL对构象（trans / gauche）的影响。脂膜的烃链区域的状态和极性/非极性膜界面的水合状态也通过Res进行调节，具体取决于膜的相态。