Kenaf (Hibiscus cannabinus L.) seed oil-in-water nanoemulsions stabilized by complexation of beta-cyclodextrin with sodium caseinate and Tween 20 have been shown to have higher bioaccessibility of vitamin E and total phenolic content than nonemulsified kenaf seed oil in the previous in vitro gastrointestinal digestion study. However, its oral bioavailability was unknown. Therefore, the aim of this study was to evaluate the rate of in vivo oral bioavailability of kenaf seed oil-in-water nanoemulsions in comparison with nonemulsified kenaf seed oil and kenaf seed oil macroemulsions during the 180 min of gastrointestinal digestion. Kenaf seed oil macroemulsions were produced by using conventional method. Kenaf seed oil-in-water nanoemulsions had shown improvement in the rate of absorption. At 180 min of digestion time, the total α-tocopherol bioavailability of kenaf seed oil nanoemulsions was increased by 1.7- and 1.4-fold, compared to kenaf seed oil and macroemulsion, respectively. Kenaf seed oil-in-water nanoemulsions were stable in considerably wide range of pH (>5 and <3), suggesting that it can be fortified into beverages within this pH range PRACTICAL APPLICATION: The production of kenaf seed oil-in-water nanoemulsions had provided a delivery system to encapsulate the kenaf seed oil, as well as enhanced the bioaccessibility and bioavailability of kenaf seed oil. Therefore, kenaf seed oil-in-water nanoemulsions exhibit a great potential application in nutraceutical fields.

中文翻译：

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乳化方法和粒径对红麻 (Hibiscus cannabinus L.) 种子油体内口服生物利用度的影响

通过 β-环糊精与酪蛋白酸钠和吐温 20 络合稳定的红麻 (Hibiscus cannabinus L.) 种子水包油纳米乳液已被证明比之前的非乳化红麻种子油具有更高的维生素 E 和总酚含量的生物可及性体外胃肠消化研究。然而，其口服生物利用度未知。因此，本研究的目的是评估红麻籽水包油纳米乳与非乳化红麻籽油和红麻籽油粗乳液相比，在 180 分钟的胃肠消化过程中的体内口服生物利用度。红麻籽油粗乳液使用常规方法生产。洋麻种子水包油纳米乳剂显示出吸收率的提高。在 180 分钟的消化时间，与洋麻籽油和粗乳液相比，红麻籽油纳米乳液的总 α-生育酚生物利用度分别增加了 1.7 倍和 1.4 倍。红麻籽水包油纳米乳液在相当宽的 pH 值范围内（>5 和 <3）稳定，表明它可以在该 pH 值范围内强化到饮料中 实际应用：红麻籽水包油纳米乳液的生产提供了一种递送系统来封装红麻籽油，并提高了红麻籽油的生物可及性和生物利用度。因此，红麻籽水包油纳米乳在营养保健领域具有巨大的应用潜力。红麻籽水包油纳米乳液在相当宽的 pH 值范围内（>5 和 <3）稳定，表明它可以在该 pH 值范围内强化到饮料中 实际应用：红麻籽水包油纳米乳液的生产提供了一种递送系统来封装红麻籽油，并提高了红麻籽油的生物可及性和生物利用度。因此，红麻籽水包油纳米乳在营养保健领域具有巨大的应用潜力。红麻籽水包油纳米乳液在相当宽的 pH 值范围内（>5 和 <3）稳定，表明它可以在该 pH 值范围内强化到饮料中 实际应用：红麻籽水包油纳米乳液的生产提供了一种递送系统来封装红麻籽油，并提高了红麻籽油的生物可及性和生物利用度。因此，红麻籽水包油纳米乳在营养保健领域具有巨大的应用潜力。以及提高红麻籽油的生物可及性和生物利用度。因此，红麻籽水包油纳米乳在营养保健领域具有巨大的应用潜力。以及提高红麻籽油的生物可及性和生物利用度。因此，红麻籽水包油纳米乳在营养保健领域具有巨大的应用潜力。