Dual Roles of α,β‐Unsaturated Oximes in Copper Catalyzed [3+3] Cyclization: Construction of 2,4,6‐Trisubstituted Pyridines,Asian Journal of Organic Chemistry

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Dual Roles of α,β‐Unsaturated Oximes in Copper Catalyzed [3+3] Cyclization: Construction of 2,4,6‐Trisubstituted Pyridines
Asian Journal of Organic Chemistry ( IF 2.8 ) Pub Date : 2018-06-13 , DOI: 10.1002/ajoc.201800318
Jianming Liu ₁ , Shufang Zhao ₁ , Xuyang Yan ₁ , Zhixian Wang ₁ , Yanyan Zhang ₁ , Peizheng Zhao ₁ , Wenhan Fang ₁ , Kelei Zhuo ₁ , Yuanyuan Yue ₁

Affiliation

A new approach to generate 2,4,6‐trisubstituted pyridines was successfully developed based on the cyclization of α,β‐unsaturated oximes catalyzed by copper(I). The method takes advantage of the inherent properties of α,β‐unsaturated oximes to generate pyridines. In this transformation, α,β‐unsaturated oximes play dual roles in the formation of nucleophilic copper(II) enamide and as the acceptor in the Michael addition.

中文翻译：

α，β-不饱和肟在铜催化的[3 + 3]环化中的双重作用：2,4,6-三取代吡啶的构建

基于铜（I）催化的α，β-不饱和肟的环化，成功开发了一种新的生成2,4,6-三取代吡啶的方法。该方法利用了α，β-不饱和肟的固有特性来生成吡啶。在这种转化中，α，β-不饱和肟在亲核铜（II）酰胺的形成中和在迈克尔加成反应中起受体的双重作用。

更新日期：2018-06-13

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