Highly enantioselective Friedel–Crafts alkylation of N,N-dialkylanilines with trans-β-nitrostyrene catalyzed by a homochiral metal–organic framework†,Chemical Communications

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Highly enantioselective Friedel–Crafts alkylation of N,N-dialkylanilines with trans-β-nitrostyrene catalyzed by a homochiral metal–organic framework†
Chemical Communications ( IF 4.3 ) Pub Date : 2018-05-25 00:00:00 , DOI: 10.1039/c8cc03447h
Koichi Tanaka _{1,

2,

3,

4,

5} , Kenji Sakuragi _{1,

2,

3,

4,

5} , Hiroto Ozaki _{1,

2,

3,

4,

5} , Yoshiki Takada _{1,

2,

3,

4,

5}

Affiliation

The first enantioselective Friedel–Crafts alkylation of N,N-dialkylanilines with trans-β-nitrostyrene catalyzed by a homochiral metal–organic framework constructed from (R)-2,2′-dihydroxy-1,1′-binaphthyl-6,6′-dicarboxylic acid has been developed. The reaction proceeded in high yields (∼96%) with excellent enantioselectivities (∼98% ee).

中文翻译：

的高度对映选择性的Friedel-Crafts烷基化Ñ，Ñ -dialkylanilines与反式由纯手性金属-有机构架催化-β硝基苯乙烯†

（R）-2,2'-dihydroxy-1,1'-binaphthyl-6,6（6,6）构筑的手性金属-有机骨架催化的N，N-二烷基苯胺与反式-β-硝基苯乙烯的首次对映选择性Friedel-Crafts烷基化反应已经开发了'-二羧酸。反应以高产率（〜96％）和优异的对映选择性（〜98％ee）进行。

更新日期：2018-05-25

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