Arginine “Magic”: Guanidinium Like-Charge Ion Pairing from Aqueous Salts to Cell Penetrating Peptides,Accounts of Chemical Research

当前位置： X-MOL 学术 › Acc. Chem. Res. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Arginine “Magic”: Guanidinium Like-Charge Ion Pairing from Aqueous Salts to Cell Penetrating Peptides
Accounts of Chemical Research ( IF 16.4 ) Pub Date : 2018-05-25 00:00:00 , DOI: 10.1021/acs.accounts.8b00098
Mario Vazdar ₁ , Jan Heyda ₂ , Philip E. Mason ₃ , Giulio Tesei ₄ , Christoph Allolio ₅ , Mikael Lund ₄ , Pavel Jungwirth ₃

Affiliation

It is a textbook knowledge that charges of the same polarity repel each other. For two monovalent ions in the gas phase at a close contact this repulsive interaction amounts to hundreds of kilojoules per mole. In aqueous solutions, however, this Coulomb repulsion is strongly attenuated by a factor equal to the dielectric constant of the medium. The residual repulsion, which now amounts only to units of kilojoules per mole, may be in principle offset by attractive interactions. Probably the smallest cationic pair, where a combination of dispersion and cavitation forces overwhelms the Coulomb repulsion, consists of two guanidinium ions in water. Indeed, by a combination of molecular dynamics with electronic structure calculations and electrophoretic, as well as spectroscopic, experiments, we have demonstrated that aqueous guanidinium cations form (weakly) thermodynamically stable like-charge ion pairs.

中文翻译：

精氨酸“魔术”：从盐到细胞穿透肽的胍盐类电荷离子配对

这是一本教科书知识，相同极性的电荷会相互排斥。对于紧密接触的气相中的两个单价离子，这种排斥性相互作用相当于每摩尔数百千焦耳。然而，在水溶液中，该库仑斥力被强烈衰减等于介质介电常数的因子。如今，残余排斥力仅相当于每摩尔千焦耳的单位，原则上可以通过有吸引力的相互作用来抵消。可能是最小的阳离子对，由分散力和空化力共同压倒库仑排斥力，由水中的两个胍离子组成。实际上，通过将分子动力学与电子结构计算，电泳以及光谱学实验相结合，

更新日期：2018-05-25

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文本刊介绍/投稿指南11