Iridoids from the Roots of Patrinia scabra and Their Inhibitory Potential on LPS-Induced Nitric Oxide Production,Journal of Natural Products

当前位置： X-MOL 学术 › J. Nat. Prod. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Iridoids from the Roots of Patrinia scabra and Their Inhibitory Potential on LPS-Induced Nitric Oxide Production
Journal of Natural Products ( IF 3.3 ) Pub Date : 2018-05-25 00:00:00 , DOI: 10.1021/acs.jnatprod.8b00229
Da Hye Lee ₁ , Ji-Sun Shin ₁ , Shin-Young Kang ₁ , Seung-Bin Lee ₁ , Jin Su Lee ₁ , Seung Mok Ryu ₂ , Kyung Tae Lee ₁ , Dongho Lee ₂ , Dae Sik Jang ₁

Affiliation

An activity-guided fractionation procedure of the 70% aqueous EtOH extract from the roots of Patrinia scabra led to the isolation and characterization of five new iridoids, patriscabrins A–E (1–5), along with 13 known compounds. The structures of 1–5 were determined by interpretation of spectroscopic data, particularly by 1D and 2D NMR, ECD, and VCD studies. Thereafter, isolates were evaluated for their inhibitory effects on lipopolysaccharide-induced nitric oxide production in RAW 264.7 cells. Of these, the new iridoids 2 and 5 and the known lignan patrineolignan B (6) exhibited IC₅₀ values of 14.7 to 17.8 μM.

中文翻译：

从根中环烯醚萜糙叶败酱及其对LPS诱导一氧化氮合成抑制潜能

从根部的70％的含水乙醇提取物的活性引导分馏过程糙叶败酱导致了五个新的环烯醚萜的分离和表征，patriscabrins A-E（1 - 5）中，用13种已知的化合物一起。的结构1 - 5通过光谱数据，特别是通过一维和二维NMR，ECD和VCD研究的解释来确定。此后，评估分离株对RAW 264.7细胞中脂多糖诱导的一氧化氮生成的抑制作用。其中，新的虹吸体2和5以及已知的木脂体patrineolignan B（6）表现出IC ₅₀ 值为14.7至17.8μM。

更新日期：2018-05-25

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11