Targeted Discovery and Combinatorial Biosynthesis of Polycyclic Tetramate Macrolactam Combamides A–E,Organic Letters

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Targeted Discovery and Combinatorial Biosynthesis of Polycyclic Tetramate Macrolactam Combamides A–E
Organic Letters ( IF 4.9 ) Pub Date : 2018-05-24 00:00:00 , DOI: 10.1021/acs.orglett.8b01285
Yan Liu ₁ , Haoxin Wang ₂ , Rentai Song ₂ , Jining Chen ₁ , Tianhong Li ₁ , Yaoyao Li ₁ , Liangcheng Du _{2,

3} , Yuemao Shen _{1,

2}

Affiliation

Polycyclic tetramate macrolactams (PoTeMs) are a growing class of natural products with distinct structure and diverse biological activities. By promoter engineering and heterologous expression of the cryptic cbm gene cluster, four new PoTeMs, combamides A–E (1–4), were identified. Additionally, two new derivatives, combamides E (5) and F (6), were generated via combinatorial biosynthesis. Together, our findings provide a sound base for expanding the structure diversities of PoTeMs through genome mining and combinatorial biosynthesis.

中文翻译：

有针对性的发现和多环四酸酯Macrolactam Combamides A–E的组合生物合成。

多环四酸酯大内酰胺（PoTeM）是一类不断增长的天然产物，具有独特的结构和多样的生物活性。通过启动子工程和隐蔽的异源表达CBM基因簇，四个新PoTeMs，combamides A-E（1 - 4），进行了鉴定。另外，通过组合生物合成产生了两个新的衍生物，梳状酰胺E（5）和F（6）。总之，我们的发现为通过基因组挖掘和组合生物合成扩展PoTeMs的结构多样性提供了坚实的基础。

更新日期：2018-05-24

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