Searching for correlations between dietary polyphenols and risk of chronic diseases has been a challenge due to the lack of quantitative evaluation methods of long‐term exposure. We previously observed substantial DNA methylation changes in human cancer cells upon treatment with polyphenols of the stilbenoid class. When induced in normal cells, such molecular changes may persist and reflect chronic exposure.

中文翻译：

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正常细胞中 DNA 甲基化模式对膳食二苯乙烯类化合物反应的细微变化

由于缺乏长期暴露的定量评估方法，寻找膳食多酚与慢性病风险之间的相关性一直是一个挑战。我们之前观察到在用芪类多酚处理后人类癌细胞中 DNA 甲基化发生了显着变化。当在正常细胞中诱导时，这种分子变化可能会持续存在并反映出慢性暴露。