Insulin hexamer dissociation dynamics revealed by photoinduced T-jumps and time-resolved X-ray solution scattering,Photochemical & Photobiological Sciences

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Insulin hexamer dissociation dynamics revealed by photoinduced T-jumps and time-resolved X-ray solution scattering
Photochemical & Photobiological Sciences ( IF 2.7 ) Pub Date : 2018-05-25 , DOI: 10.1039/c8pp00034d
Dolev Rimmerman _{1,

2,

3,

4} , Denis Leshchev _{1,

2,

3,

4} , Darren J. Hsu _{1,

2,

3,

4} , Jiyun Hong _{1,

2,

3,

4} , Baxter Abraham _{4,

5,

6,

7} , Irina Kosheleva _{4,

8,

9} , Robert Henning _{4,

8,

9} , Lin X. Chen _{1,

2,

3,

4,

10}

Affiliation

The structural dynamics of insulin hexamer dissociation were studied by the photoinduced temperature jump technique and monitored by time-resolved X-ray scattering. The process of hexamer dissociation was found to involve several transient intermediates, including an expanded hexamer and an unstable tetramer. Our findings provide insights into the mechanisms of protien–protein association.

中文翻译：

通过光诱导的T跃迁和时间分辨X射线溶液散射揭示的胰岛素六聚体解离动力学

通过光致温度跃迁技术研究了胰岛素六聚体解离的结构动力学，并通过时间分辨X射线散射对其进行了监测。发现六聚体的解离过程涉及几种瞬时中间体，包括膨胀的六聚体和不稳定的四聚体。我们的发现提供了对蛋白质-蛋白质结合机制的见解。

更新日期：2018-07-12

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