In recent years, the rapid development of medical and pharmacological interventions has led to a steady decline in certain noncommunicable chronic diseases (NCDs), such as cancer. However, the overall incidence of cardiovascular diseases (CVDs) has not seemed to decline. CVDs have become even more prevalent in many countries and represent a global health threat and financial burden. An increasing number of epidemiological and experimental studies have demonstrated that maternal insults not only can result in birth defects but also can cause developmental functional defects that contribute to adult NCDs. In the current review, we provide an overview of evidence from both epidemiological investigations and experimental animal studies supporting the concept of developmental reprogramming of adult CVDs in offspring that have experienced prenatal inflammation exposure (PIE) during fetal development (PIE-programmed CVDs), a disease-causing event that has not been effectively controlled. This review describes the epidemiological observations, data from animal models, and related mechanisms for the pathogenesis of PIE-programmed CVDs. In addition, the potential therapeutic interventions of PIE-programmed CVDs are discussed. Finally, we also deliberate the need for future mechanistic studies and biomarker screenings in this important field, which creates a great opportunity to combat the global increase in CVDs by managing the adverse effects of inflammation for prepregnant and pregnant individuals who are at risk for PIE-programmed CVDs.

近年来，医学和药理学干预措施的快速发展导致某些非传染性慢性病（NCD）（例如癌症）的发病率稳步下降。然而，心血管疾病（CVDs）的总体发病率似乎并未下降。心血管疾病在许多国家变得更加普遍，成为全球健康威胁和经济负担。越来越多的流行病学和实验研究表明，母体的侮辱不仅会导致出生缺陷，还会导致发育功能缺陷，从而导致成人非传染性疾病。在目前的审查中，我们提供了流行病学调查和实验动物研究的证据概述，支持在胎儿发育过程中经历过产前炎症暴露 (PIE) 的后代成人 CVD 的发育重编程概念（PIE 编程的 CVD），这是一种导致疾病的事件没有得到有效控制。本综述描述了流行病学观察、来自动物模型的数据以及 PIE 程序化 CVD 发病机制的相关机制。此外，还讨论了 PIE 程序化 CVD 的潜在治疗干预。最后，我们还考虑了未来在这一重要领域进行机制研究和生物标志物筛选的必要性，