Inline, real time NMR and temperature measurements have been used to optimise the continuous flow synthesis of difluoromethyltrimethylsilane (TMSCF₂H) by the reduction of the Ruppert-Prakash reagent (TMSCF₃). These measurements were used to maximise the space-time-yield, while ensuring this exothermic process remains safe. In this way, a three-fold increase in space-time-yield was achieved compared to the reported batch procedure, isolating 25 g of pure TMSCF₂H after 105 min.

中文翻译：

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在线化学核磁共振和温度监测实现了用于商品化学合成的连续分批混合反应器

在线，实时NMR和温度测量已用于通过还原Ruppert-Prakash试剂（TMSCF ₃）优化二氟甲基三甲基硅烷（TMSCF ₂ H）的连续流合成。这些测量用于最大化时空产率，同时确保放热过程仍然安全。以这种方式，在空间-时间-产率增加三倍达到比较所报告的分批程序，隔离25克纯TMSCF的₂后105分钟小时。