Peptide Nucleic Acid Conjugated with Ruthenium‐Complex Stabilizing Double‐Duplex Invasion Complex Even under Physiological Conditions,ChemBioChem

当前位置： X-MOL 学术 › ChemBioChem › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Peptide Nucleic Acid Conjugated with Ruthenium‐Complex Stabilizing Double‐Duplex Invasion Complex Even under Physiological Conditions
ChemBioChem ( IF 2.6 ) Pub Date : 2018-06-27 , DOI: 10.1002/cbic.201800256
Masaki Hibino ₁ , Yuichiro Aiba ₁ , Yoshihito Watanabe ₂ , Osami Shoji ₁

Affiliation

Protecting peptides: A conjugate of a peptide nucleic acid (PNA) and Ru complex exhibits higher DNA‐binding affinity and invasion efficiency, even under high‐salt conditions, at which DNA binding of unmodified PNA is severely impeded. Even under physiological conditions, the Ru–PNA conjugate is effective and highly sequence specific. These findings show promise for in cellulo or in vivo applications.

中文翻译：

即使在生理条件下，肽核酸也能与钌配合物稳定的双链体侵入复合物结合。

保护肽：即使在高盐条件下，未修饰的PNA的DNA结合受到严重阻碍，肽核酸（PNA）和Ru复合物的结合物也显示出更高的DNA结合亲和力和入侵效率。即使在生理条件下，Ru – PNA偶联物也是有效的且具有高度序列特异性。这些发现显示出在纤维素或体内应用中的希望。

更新日期：2018-06-27

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11