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Kinetic Resolution of Ansa Cyclophanes by Peptide‐Catalyzed Aldol/Retro‐Aldol Reactions
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2018-08-14 , DOI: 10.1002/ejoc.201800774
Kengo Akagawa 1 , Junichi Higuchi 1 , Isao Yoshikawa 1 , Kazuaki Kudo 1
Affiliation  

Peptide‐catalyzed aldol and retro‐aldol reactions were applied to kinetic resolution of planar‐chiral ansa cyclophanes. By performing these reactions sequentially with the enantiopair of resin‐supported tripeptides, the aldol product could be obtained in a good enantiopurity.
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中文翻译:

肽催化的Aldol / Retro-Aldol反应的动力学解析Ansa Cyclophanes

肽催化的醛醇缩合酶和逆醛醇缩合反应用于平面手性ansa环烷的动力学拆分。通过与树脂支持的三肽对映体顺序进行这些反应,可以获得高对映体纯度的羟醛产物。
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更新日期:2018-08-14
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