Kinetic Resolution of Ansa Cyclophanes by Peptide‐Catalyzed Aldol/Retro‐Aldol Reactions,European Journal of Organic Chemistry

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Kinetic Resolution of Ansa Cyclophanes by Peptide‐Catalyzed Aldol/Retro‐Aldol Reactions
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2018-08-14 , DOI: 10.1002/ejoc.201800774
Kengo Akagawa ₁ , Junichi Higuchi ₁ , Isao Yoshikawa ₁ , Kazuaki Kudo ₁

Affiliation

Peptide‐catalyzed aldol and retro‐aldol reactions were applied to kinetic resolution of planar‐chiral ansa cyclophanes. By performing these reactions sequentially with the enantiopair of resin‐supported tripeptides, the aldol product could be obtained in a good enantiopurity.