Stereoselective Synthesis of C1–C7 and C6–C22 Fragments of Phostriecin, Goniothalamines, and Their Analogues,European Journal of Organic Chemistry

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Stereoselective Synthesis of C1–C7 and C6–C22 Fragments of Phostriecin, Goniothalamines, and Their Analogues
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2018-08-13 , DOI: 10.1002/ejoc.201800561
K. Purushotham Reddy ₁ , D. Vasudeva Reddy ₁ , Gowravaram Sabitha ₁

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We have designed a convergent path for the synthesis of the key fragments (C1–C7 and C6–C22) of phostriecin. The approach not only provides ready access to several biologically active molecules, such as 5‐hydroxygoniothalamin, 5‐acetoxygoniothalamin, and their analogues, but also (S)‐5‐[(S)‐1‐hydroxyallyl]furan‐2(5H)‐one derivatives with cross metathesis as the key reaction.

中文翻译：

Phostriecin，鸟苷和其类似物的C1-C7和C6-C22片段的立体选择性合成

我们设计了一条融合途径，用于合成鬼臼毒素的关键片段（C1-C7和C6-C22）。该方法不仅可以方便地获取多种生物活性分子，例如5-羟基gonththalmin，5-acetoxygoniothalamin及其类似物，而且还可以提供（S）-5 [[（S）-1-羟基烯丙基]呋喃-2（5 H）-以交叉复分解为关键反应的一种衍生物。

更新日期：2018-08-13

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