Diastereoselective addition of anisoles to N-tert-butanesulfinyl imines via four-membered lithium cycles†,Chemical Communications

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Diastereoselective addition of anisoles to N-tert-butanesulfinyl imines via four-membered lithium cycles†
Chemical Communications ( IF 4.3 ) Pub Date : 2018-05-24 00:00:00 , DOI: 10.1039/c8cc03764g
Leleti Rajender Reddy _{1,

2,

3,

4} , Sharadsrikar Kotturi _{1,

2,

3,

4} , Yogesh Waman _{1,

2,

3,

4} , Chirag Patel _{1,

2,

3,

4} , Aditya Patwa _{1,

2,

3,

4} , Rajesh Shenoy _{1,

2,

3,

4}

Affiliation

A highly regio- and diastereo-selective ortho-lithiation/addition of anisoles to N-tert-butanesulfinyl imines resulting in the selective formation of chiral α-branched amines is described. This method is also efficient for highly regioselective benzylic lithiation of o-methylanisoles, followed by diastereoselective addition to N-tert-butanesulfinyl imines.

中文翻译：

通过四元锂循环将非对映异构体选择性地添加到N-叔丁烷亚磺酰基亚胺中†

描述了对N-叔丁亚磺酰基亚胺的高度区域选择性和非对映选择性邻位锂化/添加，其导致选择性形成手性α-支化胺。该方法对于邻甲基苯甲醚的高度区域选择性的苄基化锂，然后非对映选择性地添加至N-叔丁亚磺酰基亚胺也是有效的。

更新日期：2018-05-24

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