Protein Regulation by Intrinsically Disordered Regions: A Role for Subdomains in the IDR of the HIV‐1 Rev Protein,ChemBioChem

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Protein Regulation by Intrinsically Disordered Regions: A Role for Subdomains in the IDR of the HIV‐1 Rev Protein
ChemBioChem ( IF 2.6 ) Pub Date : 2018-06-28 , DOI: 10.1002/cbic.201800192
Ofrah Faust ₁ , Dana Grunhaus ₁ , Odelia Shimshon ₂ , Eylon Yavin ₂ , Assaf Friedler ₁

Affiliation

In addition to holding the nuclear export signal (NES), the role of the disordered Rev C‐terminal domain (CTD) is to stabilize the protein and maintain its active dimeric state. Analysis of the different regions within the disordered CTD showed that different subdomains in it play different, complementary roles in regulation.