Patient-derived culture models enable assessment of drug sensitivity and can connect personalized genomics with therapeutic options. However, their clinical translation is constrained by limited fidelity. We outline how the physical microenvironment regulates cell metabolism and describe how engineered culture systems could enhance the predictive power for precision medicine.

中文翻译：

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癌症新陈代谢变得身体健康

患者来源的培养模型可以评估药物敏感性，并且可以将个性化的基因组学与治疗选择联系起来。但是，它们的临床翻译受到保真度的限制。我们概述了物理微环境如何调节细胞代谢，并描述了工程培养系统如何增强精密医学的预测能力。