We congratulate the authors of the recent paper reporting on the association between pancreatic cancer (PC) in patients with a positive family history of cancer.¹ They used an original study design allowing them to better characterize the association between family history of PC (FHPC), familial aggregation of other cancer, family history of diabetes and PC risk. They reported that the risk of PC associated with FHPC was higher among ever-smokers [odds ratio (OR) = 3.16; 95% confidence interval (CI): 2.56–5.78], particularly in those with two or more first-degree relatives affected with PC (OR = 5.41; 95% CI: 4.16–18.77).

中文翻译：

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吸烟和家族史对胰腺癌发病年龄的影响

我们祝贺最近发表有关癌症家族史阳性患者的胰腺癌（PC）之间相关性的论文的作者。¹他们使用了原始的研究设计，使他们能够更好地描述PC家族史（FHPC），其他癌症的家族聚集，糖尿病家族史和PC风险之间的关联。他们报告说，吸烟者中与FHPC相关的PC风险更高[赔率（OR）= 3.16；95％置信区间（CI）：2.56-5.78]，尤其是那些有两个或多个一级亲属受PC影响的患者（OR = 5.41； 95％CI：4.16-18.77）。