We thank Maisonneuve and Lowenfels for the attention given to our article¹ and for prompting us to further explore the role of smoking on age of pancreatic cancer (PC) diagnosis among those patients with family history of pancreatic cancer (FHPC). Indeed, as stated in their letter,² the need for examining further the impact that smoking and FHPC have on PC onset is highly relevant and justified on the grounds of the findings reported by Rulyak et al.³ and others, showing that smoking anticipates PC development. Within the PanGenEU study, we addressed the association between FHPC and PC risk in two different study designs: a case-control and a reconstructed cohort study. We have re-examined this association by smoking status and age of PC development, to respond to the question raised.

中文翻译：

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响应：根据吸烟状况和家族病史，胰腺癌发病年龄的变化

我们感谢Maisonneuve和Lowenfels对我们的文章¹的关注，并促使我们进一步探索吸烟在具有胰腺癌家族史（FHPC）的患者中对胰腺癌（PC）年龄诊断的作用。确实，正如他们在信中所述²，需要进一步研究吸烟和FHPC对PC发作的影响是高度相关的，并且根据Rulyak等人报告的发现是合理的。³和其他证据，表明吸烟预示着PC的发展。在PanGenEU研究中，我们通过两种不同的研究设计解决了FHPC和PC风险之间的关联：病例对照研究和重建队列研究。我们通过吸烟状况和PC发育年龄重新检查了这种关联，以回答提出的问题。