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Decarbonylative Coupling of α-Keto Acids and Ynamides for Synthesis of β-Keto Imides
Organic Letters ( IF 5.2 ) Pub Date : 2018-05-23 00:00:00 , DOI: 10.1021/acs.orglett.8b01302
Renjie Chen 1 , Linwei Zeng 1 , Bo Huang 1 , Yangyong Shen 1 , Sunliang Cui 1, 2
Affiliation  

A novel decarbonylative coupling of α-keto acids and ynamides with extrusion of CO for synthesis of β-keto imides is reported. This process features mild reaction conditions, a broad substrate scope, and high efficiency. An isotope-labeling reaction and GC analysis were conducted to elucidate a plausible reaction mechanism.

中文翻译:

α-酮酸和亚酰胺的脱羰偶联反应合成β-酮酰亚胺

报道了一种新颖的α-酮酸和乙酰胺的脱羰偶合与CO的挤出以合成β-酮亚胺的方法。该工艺的特点是反应条件温和,底物范围广,效率高。进行了同位素标记反应和GC分析,以阐明可能的反应机理。
更新日期:2018-05-23
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