Cyclization of Ketones with Nitriles under Base: A General and Economical Synthesis of Pyrimidines,Organic Letters

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Cyclization of Ketones with Nitriles under Base: A General and Economical Synthesis of Pyrimidines
Organic Letters ( IF 4.9 ) Pub Date : 2018-05-23 00:00:00 , DOI: 10.1021/acs.orglett.8b01324
Lebin Su ₁ , Kang Sun ₁ , Neng Pan ₁ , Long Liu ₁ , Mengli Sun ₁ , Jianyu Dong ₁ , Yongbo Zhou ₁ , Shuang-Feng Yin ₁

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A facile, general, and economical synthesis of diversely functionalized pyrimidines has been realized under basic conditions via the copper-catalyzed cyclization of ketones with nitriles. The reaction proceeds via a novel pathway involving the nitriles acting as electrophiles and consecutive C–C bond and two C–N bond formations and shows broad substrate scope and good tolerance of many important functional groups. This strategy represents a new platform for constructing pyrimidine structures.

中文翻译：

在碱的作用下，酮与腈的环化反应：嘧啶的一般和经济合成

在碱性条件下，通过铜催化的酮与腈的环化反应，已经实现了功能多样的嘧啶的简便，通用且经济的合成。该反应通过一种新颖的途径进行，该途径涉及腈类作为亲电子试剂，并具有连续的C–C键和两个C–N键形成，并显示出较宽的底物范围和对许多重要官能团的良好耐受性。该策略代表了构建嘧啶结构的新平台。

更新日期：2018-05-23

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