Understanding the effect of alkyl chains of gemini cations on the physicochemical and cellular properties of polyurethane micelles†,Biomaterials Science

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Understanding the effect of alkyl chains of gemini cations on the physicochemical and cellular properties of polyurethane micelles†
Biomaterials Science ( IF 5.8 ) Pub Date : 2018-05-23 00:00:00 , DOI: 10.1039/c8bm00431e
Zhicheng Pan _{1,

2,

3,

4,

5} , Danxuan Fang _{1,

2,

3,

4,

5} , Yuanqing Song _{1,

2,

3,

4,

5} , Nijia Song _{1,

2,

3,

4,

5} , Mingming Ding _{1,

2,

3,

4,

5} , Jiehua Li _{1,

2,

3,

4,

5} , Feng Luo _{1,

2,

3,

4,

5} , Jianshu Li _{1,

2,

3,

4,

5} , Hong Tan _{1,

2,

3,

4,

5} , Qiang Fu _{1,

2,

3,

4,

5}

Affiliation

Cationic gemini quaternary ammonium (GQA) has been used as a cell internalization promoter to improve the permeability of the cell membrane and enhance the cellular uptake. However, the effect of the alkyl chain length on the cellular properties of nanocarriers has not been elucidated yet. In this study, we developed a series of polyurethane micelles containing GQAs with various alkyl chain lengths. The alteration of the gemini alkyl chain length was found to change the distribution of GQA surfactants in the micellar structure and affect the surface charge exposure, stability, and the protein absorption properties of nanocarriers. Moreover, we also clarified the role of the alkyl chain length in tumor cell internalization and macrophage uptake of polyurethane micelles. This work provides a new understanding on the effect of the GQA alkyl chain length on the physicochemical and biological properties of nanomedicines, and offers guidance on the rational design of effective drug delivery systems where the issue of functional group exposure at the micellar surface should be considered.

中文翻译：

了解双子阳离子的烷基链对聚氨酯胶束的物理化学和细胞性能的影响†

阳离子双生子季铵盐（GQA）已用作细胞内化促进剂，以改善细胞膜的通透性并增强细胞摄取。然而，尚未阐明烷基链长度对纳米载体的细胞性质的影响。在这项研究中，我们开发了一系列含有不同烷基链长度的GQA的聚氨酯胶束。发现双子烷基链长度的改变改变了胶束结构中GQA表面活性剂的分布，并影响了纳米载体的表面电荷暴露，稳定性和蛋白质吸收性能。此外，我们还阐明了烷基链长度在肿瘤细胞内化和聚氨酯胶束摄取巨噬细胞中的作用。

更新日期：2018-05-23

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