Despite the value of cytologic evaluation of thyroid nodules in reducing the frequency of surgery for benign cases, the challenge of indeterminate nodules, with their 5% to 30% risk of becoming cancerous, remains.^1,2 Patients with indeterminate thyroid nodules have typically been recommended for surgery even though most nodules proved to be benign.³ In recent years, a commercially available gene expression classifier (GEC) test with high sensitivity and negative predictive value has been shown to reduce the number of thyroidectomies performed for benign disease.⁴

中文翻译：

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甲状腺结节A基因组测序分类器的问题及临床判断

尽管对甲状腺结节进行细胞学评估对减少良性病例的手术频率具有重要价值，但不确定结节的挑战依然存在，因为它们有5％至30％的患癌风险。^{1 ，2}例不确定甲状腺结节通常被建议接受手术，即使最结节证明是良性的。³近年来，已显示具有高灵敏度和负预测值的市售基因表达分类器（GEC）测试可减少因良性疾病而进行的甲状腺切除术的数量。⁴