Bis-reaction-trigger as a strategy to improve the selectivity of fluorescent probes†,Chemical Communications

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Bis-reaction-trigger as a strategy to improve the selectivity of fluorescent probes†
Chemical Communications ( IF 4.3 ) Pub Date : 2018-05-23 00:00:00 , DOI: 10.1039/c8cc02830c
Dan Li _{1,

2,

3,

4} , Juan Cheng _{1,

2,

3,

4} , Cheng-Kun Wang _{1,

2,

3,

4} , Huazhou Ying _{1,

2,

3,

4} , Yongzhou Hu _{1,

2,

3,

4} , Feng Han _{1,

2,

3,

4} , Xin Li _{1,

2,

3,

4}

Affiliation

By the strategy of equipping a fluorophore with two reaction triggers that are tailored to the specific chemistry of peroxynitrite, we have developed a highly selective probe for detecting peroxynitrite in live cells. Sequential response by the two triggers enabled the probe to reveal various degrees of nitrosative stress in live cells via a sensitive emission colour change.

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