Reducing Bacterial Infections and Biofilm Formation Using Nanoparticles and Nanostructured Antibacterial Surfaces,Advanced Healthcare Materials

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Reducing Bacterial Infections and Biofilm Formation Using Nanoparticles and Nanostructured Antibacterial Surfaces
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2018-05-22 , DOI: 10.1002/adhm.201800103
Gujie Mi ₁ , Di Shi ₁ , Mian Wang ₁ , Thomas J. Webster ₁

Affiliation

With the rapid spreading of resistance among common bacterial pathogens, bacterial infections, especially antibiotic‐resistant bacterial infections, have drawn much attention worldwide. In light of this, nanoparticles, including metal and metal oxide nanoparticles, liposomes, polymersomes, and solid lipid nanoparticles, have been increasingly exploited as both efficient antimicrobials themselves or as delivery platforms to enhance the effectiveness of existing antibiotics. In addition to the emergence of widespread antibiotic resistance, of equal concern are implantable device‐associated infections, which result from bacterial adhesion and subsequent biofilm formation at the site of implantation. The ineffectiveness of conventional antibiotics against these biofilms often leads to revision surgery, which is both debilitating to the patient and expensive. Toward this end, micro‐ and nanotopographies, especially those that resemble natural surfaces, and nonfouling chemistries represent a promising combination for long‐term antibacterial activity. Collectively, the use of nanoparticles and nanostructured surfaces to combat bacterial growth and infections is a promising solution to the growing problem of antibiotic resistance and biofilm‐related device infections.

中文翻译：

使用纳米颗粒和纳米结构的抗菌表面减少细菌感染和生物膜形成

随着耐药性在常见细菌病原体中的迅速传播，细菌感染，尤其是对抗生素具有抗药性的细菌感染，已引起全世界的广泛关注。鉴于此，包括金属和金属氧化物纳米颗粒，脂质体，聚合物脂质体和固体脂质纳米颗粒在内的纳米颗粒已被越来越多地用作有效的抗菌剂本身或作为增强现有抗生素有效性的递送平台。除了出现广泛的抗生素耐药性外，同样引起关注的是与植入式设备相关的感染，这种感染是由细菌粘附和随后在植入部位形成生物膜引起的。常规抗生素对这些生物膜的无效性通常会导致翻修手术，这既使病人虚弱又昂贵。为此，微形貌和纳米形貌，特别是那些类似于自然表面的形貌，以及不结垢的化学物质代表了长期抗菌活性的有希望的组合。总之，使用纳米颗粒和纳米结构表面来对抗细菌的生长和感染是解决日益增长的抗生素抗性和生物膜相关装置感染问题的有前途的解决方案。

更新日期：2018-05-22

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