Unfolding the Mysteries of Protein Metamorphosis.,ACS Chemical Biology

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Unfolding the Mysteries of Protein Metamorphosis.
ACS Chemical Biology ( IF 3.5 ) Pub Date : 2018-06-07 , DOI: 10.1021/acschembio.8b00276
Acacia F Dishman ₁ , Brian F Volkman ₁

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Since the proposal of Anfinsen's thermodynamic hypothesis in 1963, our understanding of protein folding and dynamics has gained significant appreciation of its nuance and complexity. Intrinsically disordered proteins, chameleonic sequences, morpheeins, and metamorphic proteins have broadened the protein folding paradigm. Here, we discuss noncanonical protein folding patterns, with an emphasis on metamorphic proteins, and we review known metamorphic proteins that occur naturally and that have been engineered in the laboratory. Finally, we discuss research areas surrounding metamorphic proteins that are primed for future exploration, including evolution, drug discovery, and the quest for previously unrecognized metamorphs. As we enter an age where we are capable of complex bioinformatic searches and de novo protein design, we are primed to search for previously unrecognized metamorphic proteins and to design our own metamorphs to act as targeted, switchable drugs; biosensors; and more.

中文翻译：

揭开蛋白质变态的奥秘。

自 1963 年 Anfinsen 的热力学假说提出以来，我们对蛋白质折叠和动力学的理解对其细微差别和复杂性有了重要的认识。本质上无序的蛋白质、变色序列、吗啡素和变质蛋白质拓宽了蛋白质折叠范式。在这里，我们讨论了非经典蛋白质折叠模式，重点是变质蛋白质，我们回顾了已知的自然发生和在实验室中设计的变质蛋白质。最后，我们讨论了围绕变质蛋白的研究领域，这些领域为未来的探索做好了准备，包括进化、药物发现和对以前未被认识的变质蛋白的探索。随着我们进入一个能够进行复杂生物信息学搜索和从头蛋白质设计的时代，我们已经准备好寻找以前无法识别的变质蛋白，并设计我们自己的变质蛋白作为靶向、可切换的药物；生物传感器；和更多。

更新日期：2018-05-22

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