An efficient nickel-promoted selective monocyanation of benzamides with TMSCN via 8-aminoquinoline directed ortho C–H activation has been developed. Varieties of functionalized ortho-cyanated (hetero)aryl nitriles can be selectively synthesized in moderate to good yields. These cyanation products can be easily transformed into various 3-imino-1-oxoisoindolines in a one-pot procedure. The mild reaction conditions, use of cheap and commercially available reagents, wide functional group tolerance, and operational convenience make this protocol practical to the synthetic community.

中文翻译：

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镍促进的C（sp ²）–H氰基选择性合成芳基腈和3-Imino-1-氧代异吲哚啉

已经开发出一种有效的镍促进的苯甲酰胺通过8-氨基喹啉直接邻位C–H活化与TMSCN选择性单氰化的方法。可以以中等至良好的产率选择性地合成各种官能化的正氰基化（杂）芳基腈。这些氰化产物可以通过一锅法轻松地转化为各种3-亚氨基-1-氧代异吲哚啉。温和的反应条件，使用便宜的和可商购的试剂，宽泛的官能团耐受性和操作方便性使该方案对合成界可行。