Cytotoxic and Antibacterial Eremophilane Sesquiterpenes from the Marine-Derived Fungus Cochliobolus lunatus SCSIO41401,Journal of Natural Products

当前位置： X-MOL 学术 › J. Nat. Prod. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Cytotoxic and Antibacterial Eremophilane Sesquiterpenes from the Marine-Derived Fungus Cochliobolus lunatus SCSIO41401
Journal of Natural Products ( IF 3.3 ) Pub Date : 2018-05-22 00:00:00 , DOI: 10.1021/acs.jnatprod.8b00015
Wei Fang _{1,

2} , Jianjiao Wang ₂ , Junfeng Wang ₂ , Liqiao Shi ₁ , Kunlong Li ₂ , Xiuping Lin ₂ , Yong Min ₁ , Bin Yang ₂ , Lan Tang ₃ , Yonghong Liu ₂ , Xuefeng Zhou ₂

Affiliation

Three new eremophilane sesquiterpenes, dendryphiellins H–J (1–3), and three new phthalide natural products (4–6) were isolated from the marine-derived fungus Cochliobolus lunatus SCSIO41401. Their structures including absolute configurations were determined by spectroscopic and calculated ECD analyses. Dendryphiellin I (2) showed cytotoxic and antibacterial activities against five cancer cell lines (IC₅₀ 1.4 to 4.3 μM) and three bacterial species (MIC 1.5 to 13 μg/mL), respectively. Dendryphiellin J (3), a rare naturally occurring aldoxime analogue, displayed cytotoxicities against ACHN and HepG-2 cells with IC₅₀ values of 3.1 and 5.9 μM, respectively. Further studies indicated that 3 induced apoptosis in ACHN cells in a dose- and time-dependent manner.

中文翻译：

海洋衍生真菌Cochliobolus lunatus SCSIO41401的细胞毒性和抗菌Ermophilane倍半萜烯

三个新的倍半萜烯eremophilane，dendryphiellins H-Ĵ（1 - 3），并且三个新的苯并呋喃酮的天然产物（4 - 6）从海洋来源的真菌中分离旋孢腔菌lunatus SCSIO41401。通过光谱分析和计算的ECD分析确定了它们的结构，包括绝对构型。Dendryphiellin I（2）对五种癌细胞系（IC ₅₀ 1.4至4.3μM）和三种细菌种类（MIC 1.5至13μg/ mL）表现出细胞毒性和抗菌活性。Dendryphiellin J（3），一种罕见的天然醛固酮类似物，具有IC ₅₀对ACHN和HepG-2细胞的细胞毒性分别为3.1和5.9μM。进一步的研究表明3以剂量和时间依赖性方式诱导ACHN细胞凋亡。

更新日期：2018-05-22

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11