An organocatalytic chemo- and enantioselective vinylogous aldol/cyclization cascade reaction between β,γ-unsaturated amides and β,γ-unsaturated α-keto esters was developed. With 5 mol% of chiral tertiary amine-thiourea catalyst C3, highly functionalized 5,6-dihydropyran-2-ones with a quaternary stereocenter were constructed in a straightforward manner with high yields (up to 99%) and excellent enantioselectivities (up to 98% ee).

中文翻译：

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高度化学和对映选择性乙烯基醇醛/环化级联反应，以构建手性5,6-二氢吡喃-2-酮

开发了β，γ-不饱和酰胺与β，γ-不饱和α-酮酯之间的有机催化化学和对映选择性乙烯基醇醛/环化级联反应。用5 mol％的手性叔胺-硫脲催化剂C3，可以直接，高收率（高达99％）和出色的对映选择性（高达98）构建具有四级立体中心的高度官能化的5,6-二氢吡喃-2-酮。 ％ee）。