Water proton NMR detection of amide hydrolysis and diglycine dimerization†,Chemical Communications

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Water proton NMR detection of amide hydrolysis and diglycine dimerization†
Chemical Communications ( IF 4.3 ) Pub Date : 2018-05-21 00:00:00 , DOI: 10.1039/c8cc03935f
Katharine T. Briggs _{1,

2,

3,

4} , Marc B. Taraban _{1,

2,

3,

4} , Y. Bruce Yu _{1,

2,

3,

4}

Affiliation

The transverse relaxation rate of water protons R₂(¹H₂O) is found to be sensitive to amide hydrolysis and diglycine dimerization. The results demonstrate the feasibility of using R₂(¹H₂O) as a diagnostic tool to detect chemical changes in aqueous solutions. Potential applications include drug product formulation and inspection.

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