Stroke is the primary cause of disability due to the brain's limited ability to regenerate damaged tissue. After stroke, an increased inflammatory and immune response coupled with severely limited angiogenesis and neuronal growth results in a stroke cavity devoid of normal brain tissue. In the adult, therapeutic angiogenic materials have been used to repair ischaemic tissues through the formation of vascular networks. However, whether a therapeutic angiogenic material can regenerate brain tissue and promote neural repair is poorly understood. Here we show that the delivery of an engineered immune-modulating angiogenic biomaterial directly to the stroke cavity promotes tissue formation de novo, and results in axonal networks along thee generated blood vessels. This regenerated tissue produces functional recovery through the established axonal networks. Thus, this biomaterials approach generates a vascularized network of regenerated functional neuronal connections within previously dead tissue and lays the groundwork for the use of angiogenic materials to repair other neurologically diseased tissues.

由于大脑再生受损组织的能力有限，中风是导致残疾的主要原因。中风后，炎症和免疫反应增强，血管生成和神经元生长受到严重限制，导致缺乏正常脑组织的中风腔。在成人中，已将治疗性血管生成材料用于通过形成血管网络来修复缺血组织。但是，对于治疗性血管生成材料是否能够再生脑组织并促进神经修复的了解却很少。在这里，我们表明，将工程免疫调节血管生成生物材料直接递送至中风腔可促进新组织的形成，并导致沿您生成的血管的轴突网络。这种再生的组织通过建立的轴突网络产生功能恢复。因此，这种生物材料方法在先前死亡的组织内生成了再生功能神经元连接的血管化网络，并为使用血管生成材料修复其他神经系统疾病的组织奠定了基础。