Deriving from logical and mechanical interactions between DNA strands and complexes, DNA-based artificial reaction networks (RNs) are attractive for their high programmability, as well as cascading and fan-out ability, which are similar to the basic principles of electronic logic gates. Arising from the dream of creating novel computing mechanisms, researchers have placed high hopes on the development of DNA-based dynamic RNs and have strived to establish the basic theories and operative strategies of these networks. This review starts by looking back on the evolution of DNA dynamic RNs; in particular’ the most significant applications in biochemistry occurring in recent years. Finally, we discuss the perspectives of DNA dynamic RNs and give a possible direction for the development of DNA circuits.

基于DNA链和复合物之间的逻辑和机械相互作用，基于DNA的人工反应网络（RN）具有高度的可编程性以及级联和扇出功能，这与电子逻辑门的基本原理相似，因此颇具吸引力。出于创造新型计算机制的梦想，研究人员对基于DNA的动态RN的开发寄予了很高的期望，并努力建立这些网络的基本理论和操作策略。本文首先回顾了DNA动态RN的进化。尤其是近年来在生物化学领域最重要的应用。最后，我们讨论了DNA动态RN的观点，并为DNA电路的发展提供了可能的方向。