Electrospinning was used to fabricate the different ratio of poly [(R)-3-hydroxybutyrate-co-(R)-3-hydroxyhexanoate] (PHBH)/Poly (vinyl alcohol) (PVA) blend nanofibers. These nanofibers of ratio PHBH/PVA 100/0, 90/10, 70/30, and 50/50 were prepared by using HFIP as solvent. Mixed solvent of HFIP/water was used to prepare for PHBH/PVA 30/70, 10/90 and water was used for pure PVA. The characteristic of morphology, thermal properties, miscibility, wettability, water absorption, and enzymatic biodegradable behaviour of these blend nanofibers have been investigated. The result indicated that PHBH/PVA blend nanofibers are immiscibility in the crystalline phase from DSC analysis with two peaks appear in 137 °C and 230 °C in the blend nanofibers. WAXD pattern of the blend nanofiber also exhibited the decrease of PHBH crystalline intensity with the increase of PVA content. However, FTIR spectra of blend nanofiber displayed the shift of hydroxyl and carbonyl stretching band which indicates the intermolecular interaction in amorphous phase. The water contact angle values increased with the increase of PVA content more than 30%. These showed the surface of blend nanofibers were hydrophobic since WCA value was more than 90°. The increase of WCA value is due to surface morphological change that is the decrease of fiber diameter. Nevertheless, blend nanofibers of PHBH/PVA of 70/30 exhibited the high water absorption more than 350% from initial weight. SEM-photograph of samples after immersing in the water showed that structure of nanofiber did not change in blend ratio of more over 50% PHBH content. These nanofibers of pure PHBH and ratio PHBH/PVA of 90/10, 70/30, and 50/50 will expect to be useful material to have the biocompatibility with cell attachment. In vitro enzymatic biodegradable resulted that degradation rate of blend nanofiber can be greatly improved by ratio of PVA polymer. NIH3T3 cells attached and proliferated well on pure PHBH nanofiber. However, blend nanofibers with PVA-rich content inhibited growth of the NIH3T3 cells.

使用静电纺丝制造不同比例的聚[（R）-3-羟基丁酸酯-co-（R）-3-羟基己酸酯]）（PHBH）/聚乙烯醇（PVA）混合纳米纤维。通过使用HFIP作为溶剂来制备这些PHBH / PVA比为100 / 0、90 / 10、70 / 30和50/50的纳米纤维。HFIP /水的混合溶剂用于制备PHBH / PVA 30 / 70、10 / 90，水用于纯PVA。已经研究了这些共混纳米纤维的形态，热性能，可混溶性，润湿性，吸水率和酶促生物降解行为。结果表明，PHBH / PVA共混纳米纤维在DSC分析的结晶相中不溶混，共混纳米纤维在137°C和230°C出现两个峰。随着PVA含量的增加，共混纳米纤维的WAXD图案也表现出PHBH结晶强度的降低。然而，共混纳米纤维的FTIR光谱显示了羟基和羰基拉伸带的移动，这表明了非晶相中的分子间相互作用。水接触角值随PVA含量增加30％以上而增加。这些表明，由于WCA值大于90°，​​共混纳米纤维的表面是疏水的。WCA值的增加归因于表面形态的变化，即纤维直径的减小。然而，PHBH / PVA为70/30的共混纳米纤维表现出比初始重量高350％以上的高吸水率。浸入水中的样品的SEM照片显示，超过50％的PHBH含量，纳米纤维的结构没有发生变化。这些纯PHBH和PHBH / PVA之比分别为90 / 10、70 / 30，体外酶法可生物降解的结果表明，PVA聚合物的比例可以大大提高共混纳米纤维的降解率。NIH3T3细胞在纯PHBH纳米纤维上附着并增殖良好。但是，具有丰富PVA含量的混合纳米纤维会抑制NIH3T3细胞的生长。