Hydrogel-based drug delivery systems (DDSs) have versatile applications such, as tissue engineering, scaffolds, drug delivery, and regenerative medicines. The drawback of higher size and poor stability in such DDSs are being addressed by developing nano-sized hydrogel particles, known as nanogels, to achieve the desired biocompatibility and encapsulation efficiency for better efficacy than conventional bulk hydrogels. In this review, we describe advances in the development of nanogels and their promotion as nanocarriers to deliver therapeutic agents to the central nervous system (CNS). We also discuss the challenges, possible solutions, and future prospects for the use of nanogel-based DDSs for CNS therapies.

基于水凝胶的药物递送系统（DDS）具有多种应用，例如组织工程、支架、药物递送和再生医学。通过开发纳米水凝胶颗粒（称为纳米凝胶）来解决此类 DDS 尺寸较大和稳定性较差的缺点，以实现所需的生物相容性和封装效率，从而比传统的本体水凝胶具有更好的功效。在这篇综述中，我们描述了纳米凝胶的开发进展及其作为纳米载体向中枢神经系统（CNS）输送治疗剂的推广。我们还讨论了使用基于纳米凝胶的 DDS 进行中枢神经系统治疗的挑战、可能的解决方案和未来前景。