E-cadherin is a key component of the adherens junctions that are integral in cell adhesion and maintaining epithelial phenotype of cells. Homophilic E-cadherin binding between cells is important in mediating contact inhibition of proliferation when cells reach confluence. Loss of E-cadherin expression results in loss of contact inhibition and is associated with increased cell motility and advanced stages of cancer. In this review we discuss the role of E-cadherin and its downstream signaling in regulation of contact inhibition and the development and progression of cancer.

中文翻译：

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E-钙粘蛋白在接触抑制和癌症中的作用。

E-钙粘着蛋白是粘附连接的关键成分，其在细胞粘附和维持细胞的上皮表型中是不可或缺的。当细胞达到汇合时，细胞之间的亲和性E-钙粘着蛋白结合在介导增殖的接触抑制中很重要。E-钙粘着蛋白表达的丧失导致接触抑制的丧失，并且与细胞运动性增加和癌症的晚期有关。在这篇综述中，我们讨论了E-钙粘蛋白及其下游信号传导在调节接触抑制以及癌症发展和进程中的作用。