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A fast and practical synthesis of tert-butyl esters from 2-tert-butoxypyridine using boron trifluoride·diethyl etherate under mild conditions
Tetrahedron ( IF 2.1 ) Pub Date : 2018-05-19 , DOI: 10.1016/j.tet.2018.05.050
Minh Thanh La , Hee-Kwon Kim

A practical direct preparation of tert-butyl esters from 2-tert-butoxypyridine has been developed. This system features the use of boron trifluoride·diethyl etherate in toluene solvent to rapidly achieve the reaction at room temperature. Using this reaction protocol, a variety of tert-butyl esters were synthesized from several different carboxylic acids at high yields. This practical procedure provides a promising and effective approach to the protection of carboxylic acids with a tert-butyl group.



中文翻译:

在温和的条件下,使用三氟化硼·二乙醚快速,实用地由2-叔丁氧基吡啶合成丁酯

已经开发了从2-叔丁氧基吡啶实际直接制备丁酯的方法。该系统的特点是在甲苯溶剂中使用三氟化硼·乙醚乙醚,可在室温下快速完成反应。使用该反应方案,由几种不同的羧酸以高收率合成了多种丁酯。该实用方法为保护具有丁基的羧酸提供了一种有前途和有效的方法。

更新日期:2018-05-19
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