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Incorporation of a Theranostic “Two-Tone” Luminescent Silver Complex into Biocompatible Agar Hydrogel Composite for the Eradication of ESKAPE Pathogens in a Skin and Soft Tissue Infection Model
Inorganic Chemistry ( IF 4.3 ) Pub Date : 2018-05-18 00:00:00 , DOI: 10.1021/acs.inorgchem.8b00901 Miguel N. Pinto 1 , Jorge Martinez-Gonzalez 1 , Indranil Chakraborty 1 , Pradip K. Mascharak 1
Inorganic Chemistry ( IF 4.3 ) Pub Date : 2018-05-18 00:00:00 , DOI: 10.1021/acs.inorgchem.8b00901 Miguel N. Pinto 1 , Jorge Martinez-Gonzalez 1 , Indranil Chakraborty 1 , Pradip K. Mascharak 1
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Microbial invasion and colonization of the skin and underlying soft tissues are among the most common types of infections, becoming increasingly prevalent in hospital settings. Systemic antibiotic chemotherapies are now extremely limited due to emergence of drug-resistant Gram-positive and multidrug-resistant Gram-negative bacterial strains. Topical administration of antimicrobials provides an effective route for the treatment of skin and soft tissue infections (SSTIs). Therefore, the development of new and effective materials for the delivery of these agents is of paramount importance. Silver is a broad-spectrum antibiotic used for the treatment and prevention of infections since ancient times. However, the high reactivity of silver cation (Ag+) makes its incorporation into delivery materials quite challenging. Herein we report a novel soft agar hydrogel composite for the delivery of Ag+ into infected wound sites. This material incorporates a Ag(I) complex [Ag2(DSX)2(NO3)2] (1; DSX = 5-(dimethylamino)-N,N-bis(pyridin-2-ylmethyl) naphthalene-1-sulfonamide) that exhibits a change in fluorescence upon Ag+ release and qualitatively indicates the end point of silver delivery. The antibacterial efficacy of the material was tested against several bacterial strains in an SSTI model. The complex 1–agar composite proved effective at eradicating the pathogens responsible for the majority of SSTIs. The theranostic (therapeutic/diagnostic) properties coupled with its stability, softness, ease of application, and removal make this material an attractive silver-delivery vehicle for the treatment and prevention of SSTIs.
中文翻译：
在皮肤和软组织感染模型中消灭ESKAPE病原体的生物相容性琼脂水凝胶复合物中掺入了一种治疗性的“双音”发光银络合物到生物相容性琼脂水凝胶复合物中。
皮肤和下面的软组织的微生物入侵和定植是最常见的感染类型，在医院环境中变得越来越普遍。由于出现耐药性的革兰氏阳性和多重耐药的革兰氏阴性细菌菌株，目前系统的抗生素化学疗法受到极大限制。局部施用抗菌素为治疗皮肤和软组织感染（SSTI）提供了有效途径。因此，开发用于递送这些试剂的新的有效材料至关重要。银是一种广谱抗生素，自古以来就用于治疗和预防感染。但是，银阳离子（Ag +）使得将其合并到交付材料中具有很大的挑战性。在这里，我们报告了一种新型的软琼脂水凝胶复合材料，用于将Ag +输送到感染的伤口部位。该材料包含Ag（I）络合物[Ag 2（DSX）2（NO 3）2 ]（1； DSX = 5-（二甲基氨基）-N，N-双（吡啶-2-基甲基）萘-1-磺酰胺）在释放Ag +时荧光发生变化，并定性地指示了银释放的终点。在SSTI模型中测试了该材料对几种细菌菌株的抗菌功效。复杂1事实证明，琼脂复合材料可有效根除造成大多数SSTI的病原体。治疗性（治疗性/诊断性）性质及其稳定性，柔软性，易用性和去除性使其成为治疗和预防SSTI的引人注目的银载运载体。
更新日期：2018-05-18
中文翻译：
在皮肤和软组织感染模型中消灭ESKAPE病原体的生物相容性琼脂水凝胶复合物中掺入了一种治疗性的“双音”发光银络合物到生物相容性琼脂水凝胶复合物中。
皮肤和下面的软组织的微生物入侵和定植是最常见的感染类型，在医院环境中变得越来越普遍。由于出现耐药性的革兰氏阳性和多重耐药的革兰氏阴性细菌菌株，目前系统的抗生素化学疗法受到极大限制。局部施用抗菌素为治疗皮肤和软组织感染（SSTI）提供了有效途径。因此，开发用于递送这些试剂的新的有效材料至关重要。银是一种广谱抗生素，自古以来就用于治疗和预防感染。但是，银阳离子（Ag +）使得将其合并到交付材料中具有很大的挑战性。在这里，我们报告了一种新型的软琼脂水凝胶复合材料，用于将Ag +输送到感染的伤口部位。该材料包含Ag（I）络合物[Ag 2（DSX）2（NO 3）2 ]（1； DSX = 5-（二甲基氨基）-N，N-双（吡啶-2-基甲基）萘-1-磺酰胺）在释放Ag +时荧光发生变化，并定性地指示了银释放的终点。在SSTI模型中测试了该材料对几种细菌菌株的抗菌功效。复杂1事实证明，琼脂复合材料可有效根除造成大多数SSTI的病原体。治疗性（治疗性/诊断性）性质及其稳定性，柔软性，易用性和去除性使其成为治疗和预防SSTI的引人注目的银载运载体。
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