A Rapidly Self‐Healing Host–Guest Supramolecular Hydrogel with High Mechanical Strength and Excellent Biocompatibility,Angewandte Chemie International Edition

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A Rapidly Self‐Healing Host–Guest Supramolecular Hydrogel with High Mechanical Strength and Excellent Biocompatibility
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2018-06-19 , DOI: 10.1002/anie.201804400
Zhifang Wang ₁ , Yipeng Ren ₂ , Ye Zhu ₃ , Lijing Hao ₁ , Yunhua Chen ₁ , Geng An ₄ , Hongkai Wu ₅ , Xuetao Shi ₁ , Chuanbin Mao _{3,

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Affiliation

It is still a challenge to achieve both excellent mechanical strength and biocompatibility in hydrogels. In this study, we exploited two interactions to form a novel biocompatible, slicing‐resistant, and self‐healing hydrogel. The first was molecular host–guest recognition between a host (isocyanatoethyl acrylate modified β‐cyclodextrin) and a guest (2‐(2‐(2‐(2‐(adamantyl‐1‐oxy)ethoxy)ethoxy)ethoxy)ethanol acrylate) to form “three‐arm” host–guest supramolecules (HGSMs), and the second was covalent bonding between HGSMs (achieved by UV‐initiated polymerization) to form strong cross‐links in the hydrogel. The host–guest interaction enabled the hydrogel to rapidly self‐heal. When it was cut, fresh surfaces were formed with dangling host and guest molecules (due to the breaking of host–guest recognition), which rapidly recognized each other again to heal the hydrogel by recombination of the cut surfaces. The smart hydrogels hold promise for use as biomaterials for soft‐tissue repair.

中文翻译：

具有高机械强度和优异生物相容性的快速自我修复宿主-客体超分子水凝胶

在水凝胶中实现优异的机械强度和生物相容性仍然是一个挑战。在这项研究中，我们利用两种相互作用形成了一种新型的生物相容性，抗切片性和自愈性水凝胶。首先是宿主（丙烯酸异氰酸根合乙酯改性的β-环糊精）和客体（丙烯酸2-（2-（2-（2-（2-金刚烷-1-氧基）乙氧基）乙氧基）乙氧基）乙醇）之间的分子主体-客体识别。形成“三臂”主客体超分子（HGSM），第二个是HGSM之间的共价键合（通过UV引发的聚合反应实现），从而在水凝胶中形成牢固的交联键。主客体相互作用使水凝胶能够快速自我修复。切割后，新表面形成了悬挂的主体和客体分子（由于破坏了主体-客体的识别），通过切割表面的重组，彼此迅速地相互识别，从而治愈了水凝胶。智能水凝胶有望用作软组织修复的生物材料。

更新日期：2018-06-19

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