A Et₃N-mediated Neber reaction of aryl/alkyl-2,2,2-trifluoroethylketoximes has been developed. This one-pot metal-free protocol enables the facile construction of an array of trifluoromethyl-substituted azirines in moderate to high yields under mild reaction conditions. Further transformations of azirines to CF₃-containing pyrrole and amino-alcohol derivatives are also demonstrated.

中文翻译：

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通过一锅无金属Neber反应轻松构建三氟甲基叠氮基

已经开发了由Et ₃ N介导的芳基/烷基-2,2,2-三氟乙基酮肟的奈伯反应。此一锅无金属方案可在温和的反应条件下以中等至高收率轻松构建三氟甲基取代的叠氮基阵列。还证明了叠氮基向含CF ₃的吡咯和氨基醇衍生物的进一步转化。