Abstract Efficient theranostic tools are today more and more frequently represented by the nano-sized systems. In this paper, polymeric micelles were produced and exploited to encapsulate both an antitumor drug (Doxorubicin) and gold core–shell quantum dots nanoparticles (Au-SiO2/QDs). α,β-poly(N-hydroxyethyl)- dl -aspartamide (PHEA) was functionalized with lipoic acid (LA), polyethylenglycol (PEG), and folic acid (FA) pendant moieties to obtain a synthetic derivative (PHEA-LA-PEG-FA) able to self assemble in aqueous medium giving rise to the formation of polymeric micelles exposing on their surface both targeting groups (FA) and hydrophilic chains (PEG). The drug carrying ability of PHEA-LA-PEG-FA micelles was here studied along with the cytotoxity of the obtained nanostructures toward breast cancer cells employing doxorubicin as a model anticancer drug. Finally, the properties of the gold-shell QDs incorporated into the micelles as cells imaging agent and photothermal anticancer treatment tool were explored.

中文翻译：

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封装在聚合物胶束中的混合金/二氧化硅/量子点超分子纳米结构作为靶向癌症治疗的潜在治疗诊断工具

摘要 高效的诊疗工具如今越来越多地以纳米级系统为代表。在本文中，聚合物胶束被生产并用于封装抗肿瘤药物（阿霉素）和金核壳量子点纳米粒子（Au-SiO2/QDs）。α,β-聚(N-羟乙基)-dl-天冬酰胺 (PHEA) 用硫辛酸 (LA)、聚乙二醇 (PEG) 和叶酸 (FA) 悬垂部分官能化以获得合成衍生物 (PHEA-LA-PEG) -FA) 能够在水性介质中自组装，从而形成聚合物胶束，在其表面暴露靶向基团 (FA) 和亲水链 (PEG)。这里研究了 PHEA-LA-PEG-FA 胶束的载药能力以及所获得的纳米结构对采用阿霉素作为模型抗癌药物的乳腺癌细胞的细胞毒性。最后，探索了掺入胶束中的金壳量子点作为细胞显像剂和光热抗癌治疗工具的特性。