We have demonstrated three component reaction of isatin, enaminone and ethyl cyanoacetate leading to sprirooxindole scaffold without catalyst in water. The synthetic protocol has several advantages like wide substrate scope, atom-economy and operationally simple experimental procedures which provides rapid access to library of compounds. The mechanistic details of the reaction has been investigated during the course of study.

中文翻译：

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通过isatin反应，快速进入2,5'-dioxo-5'，6'，7'，8'-tetrahydro-1'H-spiro [indoline-3,4'-quinoline] -3'-羧酸盐，水中的氰基乙酸乙酯和烯胺

我们已经证明了靛红，烯胺酮和氰基乙酸乙酯的三组分反应在没有催化剂的情况下导致了斯普罗吲哚骨架。合成规程具有多种优势，例如底物范围广，原子经济和操作简单的实验程序，可快速访问化合物库。在研究过程中已经研究了反应的机理细节。