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Metal-Free-Visible Light C–H Alkylation of Heteroaromatics via Hypervalent Iodine-Promoted Decarboxylation
Organic Letters ( IF 4.9 ) Pub Date : 2018-05-16 00:00:00 , DOI: 10.1021/acs.orglett.8b01085
Julien Genovino 1 , Yajing Lian 1 , Yuan Zhang 1 , Taylor O. Hope 2 , Antoine Juneau 2 , Yohann Gagné 2 , Gajendra Ingle 1 , Mathieu Frenette 2
Affiliation  

A metal-free photoredox C–H alkylation of heteroaromatics from readily available carboxylic acids using an organic photocatalyst and hypervalent iodine reagents under blue LED light is reported. The developed methodology tolerates a broad range of functional groups and can be applied to the late-stage functionalization of drugs and drug-like molecules. The reaction mechanism was investigated with control experiments and photophysical experiments as well as DFT calculations.

中文翻译:

通过高价碘促进脱羧的杂芳烃的无金属可见光CH烷基化

据报道,在蓝色LED灯下,使用有机光催化剂和高价碘试剂可将易得的羧酸中的杂芳烃进行无金属的光氧化还原C–H烷基化反应。所开发的方法可以耐受各种官能团,并且可以应用于药物和类药物分子的后期功能化。通过控制实验,光物理实验以及DFT计算研究了反应机理。
更新日期:2018-05-16
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