Layer‐by‐layer assembled polymeric multilayer capsules (PMC) of micrometer sizes are permeable for molecules below 1 KDa; therefore, the efficacy of such capsules in the delivery of low molecular weight water soluble bioactive compounds and drugs is frequently challenged. Thermally induced contraction of hollow PMC is explored here to enhance their loading efficacy with model compound, fluorescent rhodamine B (RhB). Four bilayered capsules obtained of poly(diallyldimethylammonium chloride)/polystyrene sulfonate ([PDADMAC/PSS]₄) or poly‐l‐arginine/dextran sulfate ([PARG/DS]₄) on sacrificial CaCO₃ spherical microparticles are postloaded with RhB at ambient or elevated temperatures. The influence of heat on capsule loading is determined quantitatively by varying the amounts of capsules in the batch and keeping the concentration of RhB constant. The applied heat improves the loading efficacy of [PDADMAC/PSS]₄ capsules at concentrations up to 2.25 × 10⁹ capsules mL⁻¹, but has a reversed effect on [PARG/DS]₄ capsules at all studied concentrations ((0–3.5) × 10⁹ capsules mL⁻¹).

中文翻译：

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热处理对若丹明B对聚合物多层微胶囊载量的影响

微米级大小的逐层组装的聚合物多层胶囊（PMC）可渗透低于1 KDa的分子。因此，这种胶囊在递送低分子量水溶性生物活性化合物和药物中的功效经常受到挑战。本文探讨了空心PMC的热诱导收缩，以增强其与模型化合物荧光若丹明B（RhB）的负载效果。在牺牲CaCO ₃上获得四个聚二烯丙基二甲基氯化铵/聚苯乙烯磺酸盐（[PDADMAC / PSS] ₄）或聚l-精氨酸/硫酸葡聚糖（[PARG / DS] ₄）双层胶囊。球形微粒在环境温度或高温下后装RhB。通过改变批次中胶囊的数量并保持RhB的浓度恒定，可以定量确定热量对胶囊负载的影响。所施加的热量提高了[PDADMAC / PSS] ₄胶囊在高达2.25×10 ⁹胶囊mL ^-1的浓度下的装载效率，但在所有研究浓度下对[PARG / DS] ₄胶囊的作用却相反（（0-3.5 ）×10 ⁹胶囊mL ^-1）。