Consumption of capsaicin or its nonpungent analogues, capsinoids has been reported to affect energy expenditure and fat oxidation, although available data are still controversial. The aim of the present study was to conduct a meta-analysis regarding the effects of these substances on energy expenditure and respiratory quotient, with special emphasis on the role of body mass index (BMI) of the participants. Medical databases were systematically searched for papers. Of the 627 trials identified, 9 provided results suitable to be included in analysis. Data analysis showed that after ingestion of capsaicin or capsinoids the energy expenditure increased (245 kJ/day, 58.56 kcal/day, p = 0.030) and the respiratory quotient decreased (by 0.216; p = 0.031) indicating a rise in fat oxidation. Studies with mean BMI of the participants below 25 kg/m² failed to report any effect of capsaicin or capsinoids on the energy expenditure (p = 0.718) or on the respiratory quotient (p = 0.444), but studies with mean BMI exceeding 25 kg/m² demonstrated an increase in energy expenditure (292 kJ/day, 69.79 kcal/day, p = 0.023) and a marked decrease in respiratory quotient (−0.257, p = 0.036). Our data clearly suggest that capsaicin or capsiate could be a new therapeutic approach in obesity promoting a negative energy balance and increased fat oxidation.

中文翻译：

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辣椒素和辣椒碱可能是治疗肥胖的合适药物：一项对人体研究的荟萃分析

尽管已有数据尚存争议，但据报道食用辣椒素或其非刺激性类似物辣椒素会影响能量消耗和脂肪氧化。本研究的目的是对这些物质对能量消耗和呼吸商的影响进行荟萃分析，并特别强调参与者体重指数（BMI）的作用。系统地搜索医学数据库中的论文。在确定的627个试验中，有9个提供了适合纳入分析的结果。数据分析表明，摄入辣椒素或类辣椒素后，能量消耗增加（245 kJ /天，58.56 kcal /天，p = 0.030），呼吸商减少（减少0.216；p= 0.031）表示脂肪氧化增加。参与者平均BMI低于25 kg / m ^2的研究未能报告辣椒素或辣椒素对能量消耗（p = 0.718）或呼吸商（p = 0.444）的任何影响，但研究表明BMI平均超过25 kg / m ²证明能量消耗增加（292 kJ /天，69.79 kcal /天，p = 0.023）和呼吸商显着下降（-0.257，p = 0.036）。我们的数据清楚地表明，辣椒素或辣椒碱可能是肥胖症中一种新的治疗方法，可促进能量负平衡并增加脂肪氧化。