To the Editor—The paper by Repetto et al. [1] plainly suggests that ivermectin is unable to cure chronic strongyloidiasis. Ivermectin is the drug of choice for this parasite, and its efficacy has been confirmed by all randomized clinical trials (RCT) conducted so far (resumed in Table 1 in the same article). Moreover, 2 epidemiological studies conducted in endemic areas clearly showed that, where ivermectin was regularly used for onchcerciasis or bancroftian filariasis, the prevalence of strongyloidiasis declined dramatically and remained very low for years after mass administration was interrupted [2, 3]. Now, a small observational study that lost at follow-up 50 out of the 71 subjects initially diagnosed (23 left without treatment and 27 missed after treatment) claims that ivermectin can virtually never achieve cure! The patients were monitored for up to 4 years, and polymerase chain reaction (PCR) was positive at all post-treatment controls.

中文翻译：

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伊维菌素对类圆线虫病无效吗？

致编辑-Repetto等人的论文。[1]明确表明，伊维菌素不能治愈慢性圆线虫病。伊维菌素是该寄生虫的首选药物，迄今为止，所有已进行的随机临床试验（RCT）均证实了其功效（在同一篇文章的表1中进行了总结）。此外，在流行地区进行的2项流行病学研究清楚地表明，在伊维菌素经常用于盘尾丝虫病或班克罗夫特氏丝虫病的情况下，大规模接种被中断后，多年生强线虫病的发生率显着下降，并且仍然很低[2，3]。现在，一项小型观察性研究在随访中失去了最初诊断的71位受试者中的50位（23位未经治疗而遗失27位在治疗后遗失），声称依维菌素实际上永远无法治愈！